During my travels I have avoided staying with family & friends. Therefore, I have spent many nights in hotels (when not on a plane, boat, or train (never slept in the car, at least over night).
My favorites are:
Choice Properties:
Comfort Inn, Comfort Suites, Quality Inn, Sleep Inn, Clarion, Cambria Suites, Mainstay Suites, Suburban, EconoLodge, and Rodeway Inn.
Hilton:
Walsorf Astoria, Conrad, Hilton, DoubleTree, Embassy Suites, Hilton Garden Inn, Hamption, Homewood Suites, Home2, and Hilton Grand Vacations.
Marriott:
Marriott Hotels & Resorts, JW Marriott Hotels & Resorts, Renaissance Hotels, EDITION Hotels, Autograph Collection, Courtyard by Marriott, AC Hotels by Marriott, Residence Inn by Marriott, Fairfield Inn & Suites by Marriott, Marriot Conference Centers, TownePlace Suites by Marriott, SpringHill Suites by Marriott, Marriot Vacation Club, The Ritz-Carlton, ExecuStay, Marriott Executive Apartments, and Grand Residences by Marriott.
Starwood:
LeMeridan, aLoft, Westin, Four Points, Element, Sheraton, St. Regis, and W.